Table A2.

Search terms and search strategy in Scopus database.

Domain	No.	Search Terms: TITLE-ABS-KEY
P 1	#1	“breast cancer”
	#2	“breast neoplasms”
P 1	#3	#1 OR #2
P 2	#4	“human epidermal growth factor receptor 2”
	#5	“HER2”
	#6	“ERBB2”
P 2	#7	#4 OR #5 OR #6
P	#8	P1 AND P2 #3 AND #7
I 1	#9	“neoadjuvant”
	#10	“pre operative”
	#11	#9 OR #10
I 2	#12	“anti HER2” OR “anti human epidermal growth factor receptor 2”
	#13	“targeted therapy”
	#14	“trastuzumab” OR “Herceptin”
	#15	“pertuzumab” OR “perjeta”
	#16	“lapatinib” OR “Tykerb” OR “Tyverb”
	#17	#12 OR #13 OR #14 OR #15 OR #16
I	#18	I 1 OR I 2 #11 OR #17
O 1	#19	“complete response”
O 2	#20	“survival”
O 3	#21	“adverse event”
O	#22	O1 OR O2 OR O3 #19 OR #20 OR #21
S	#23	“randomized controlled trial”
Combinations
P, I, O	#8 AND #18 AND #22
P, I, O, S	#8 AND #18 AND #22 AND #23