Table 4.
Excess relative risks of various primary glaucoma type incidence in relation to cumulative brain absorbed dose of external gamma-ray and neutron exposure lagged for 5 years.
| Analysis | ERR/Gy (95%CI) | |||
|---|---|---|---|---|
| POAG | HTG | NTG | PACG | |
| Baseline analysis, dose lagged for 5 years |
0.07 (−0.08, 0.29) | −0.01 (−0.16, 0.20) | 0.53 (0.01, 1.68) | 0.04 (−0.51, 1.53) |
| Sensitivity analysis: dose lagging for | ||||
| 0 years | 0.07 (−0.08, 0.28) | −0.02 (−0.18, 0.18) | 0.54 (0.02, 1.70) | 0.04 (−0.50, 1.48) |
| 10 years | 0.07 (−0.08, 0.28) | −0.02 (−0.17, 0.19) | 0.53 (0.01, 1.66) | 0.06 (−0.51, 1.62) |
| 15 years | 0.07 (−0.08, 0.28) | −0.02 (−0.17, 0.19) | 0.53 (0.01, 1.67) | 0.02 (−0.51, 1.52) |
| 20 years | 0.06 (−0.09, 0.27) | −0.02 (−0.17, 0.19) | 0.48 (−0.02, 1.54) | −0.02 (−0.49, 1.22) |
| Sensitivity analysis: excluding from stratification | ||||
| Arterial hypertension | 0.08 (−0.07, 0.30) | −0.01 (−0.16, 0.19) | 0.61 (0.06, 1.81) | −0.006 (−0.48, 1.21) |
| Body mass index | 0.13 (−0.04, 0.35) | 0.02 (−0.13, 0.23) | 0.77 (0.14, 2.15) | −0.07 (−0.45, 0.90) |
| Diabetes mellitus | 0.09 (−0.06, 0.30) | 0.002 (−0.15, 0.21) | 0.54 (0.03, 1.65) | 0.03 (−0.50, 1.53) |
| Neutron dose | 0.06 (−0.08, 0.26) | −0.04 (−0.19, 0.15) | 0.65 (0.08, 1.85) | 0.08 (−0.51, 1.59) |
| Sensitivity analysis: including to stratification | ||||
| Smoking index | 0.09 (−0.07, 0.32) | −0.02 (−0.18, 0.19) | 0.74 (0.11, 2.13) | 0.19 (−0.54, 2.07) |
| Smoking and alcohol drinking habit | 0.16 (−0.03, 0.43) | 0.05 (−0.13, 0.32) | 0.72 (0.08, 2.23) | 0.22 (−0.40, 2.19) |
| Cataract | −0.02 (−0.14, 0.15) | −0.11 (−0.24, 0.05) | 0.50 (0.002, 1.59) | −0.03 (−0.48, 1.11) |
| Cataract surgery | 0.08 (−0.07, 0.30) | −0.002 (−0.16, 0.21) | 0.53 (0.008, 1.7) | 0.05 (−0.51, 1.59) |
| Sensitivity analysis: risk associated with neutron dose | ||||
| Baseline analysis, dose lagged for 5 years | 44.97 (−14.06, 132.1) | 29.3 (−22.65, 115.3) | 126.8 (−57.13, 488.8) | −5.37 (n/a, 519.0) |
CI, confidence interval; ERR/Gy, excess relative risk per unit absorbed dose; Gy, gray; n/a, not available; POAG, primary open-angle glaucoma; HTG, high-tension glaucoma; NTG, normal-tension glaucoma; PACG, primary angle-closure glaucoma; Estimates in bold are statistically significant.