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The tumorigenic capacity of APOL1 G0, G1, G2 and null RCC cancer. Cells. Cells were injected intramuscularly (IM) into mice (n = 5). (A,B) Tumors were harvested at 55 days; (C) APOL1 G0 RCC-derived tumors demonstrate a dense tissue typical of a highly aggressive epithelioid tumor. APOL1 null RCC-derived tumors exhibit a less dense tissue with multiple foci of differentiation into adipocytes (arrows). Bar = 100 µm for the upper images and 50 µm for the enlarged images.
