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. 2022 Jan 28;14(3):682. doi: 10.3390/cancers14030682

Figure 3.

Figure 3

Prognostic value of tumor-infiltrating lymphocytes. (A) Representative image of a tissue section of a melanoma metastasis stained for CD3 and CD20; shown here are an overview of the section and a region of interest. IHC slides were scanned at ×40 magnification and the images are displayed at ×2.2 (Scale bar = 500 µm) and ×10 magnification. (B–D) Kaplan–Meier estimates of RFS for intratumoral TIL (both CD3+ T cells and CD20+ B cells), CD3+ T cells and CD20+ B cells. (E–G) Kaplan–Meier estimates of RFS for peritumoral TIL (both CD3+ T cells and CD20+ B cells), CD3+ T cells and CD20+ B cells. A higher intratumoral and peritumoral TIL, CD3+ T-cell, and CD20+ B-cell presence, except for intratumoral CD20+ B cells, were significantly associated with a longer RFS.