Table 1.
Demographic and Clinical Characteristics of the Patients at Baseline.
| Characteristic | Cohort-1 | Cohort-2 |
|---|---|---|
| (n = 34) | (n = 21) | |
| Sex | Number (%) | |
| Female | 19 (56) | 11 (52) |
| Male | 15 (44) | 10 (48) |
| Age | Median (range) | |
| 54 (29–77) | 53 (36–78) | |
| Disease Stage (AJCC 8th edition) | Number (%) | |
| IIB | 1(3) | 0 (0) |
| IIIA | 0 (0) | 5 (24) |
| IIIB | 21 (62) | 5 (24) |
| IIIC | 9 (26) | 10 (48) |
| IV | 3 (9) | 1 (4) |
| BRAFV600 mutation status | Number (%) | |
| Mutant | 15 (44) | 5 (24) |
| Wild type | 17 (50) | 14 (67) |
| Unknown | 2 (6) | 2 (9) |
| Number of positive lymph nodes | Number (%) | |
| 0 | 10 (29) | 1 (4) |
| 1 | 11 (32) | 12 (57) |
| 2 | 10 (29) | 5 (24) |
| >2 | 3 (9) | 2 (15) |
| Nodal metastatic burden | Number (%) | |
| Microscopic | 2 (6) | 14 (67) |
| Macroscopic | 17 (50) | 5 (24) |
| In transit/satellite without metastatic nodes | 12 (35) | 2 (9) |
| NA | 3 (9) | 0 (0) |
| Primary tumor ulceration | Number (%) | |
| With ulceration | 11 (32) | 5 (24) |
| Without ulceration | 10 (30) | 11 (52) |
| Unknown | 13 (38) | 5 (24) |
Microscopic: non-clinically detected disease; macroscopic: clinically detected disease Abbreviations: AJCC: American Joint Committee on Cancer; NA: not applicable.