Table 3.
Treatment-emergent adverse events leading to dose reduction and subsequently to dose discontinuation.
| Event or Abnormality | Grade | Onset Time (Cycle) | Permanent Discontinuation | Time of Discontinuation (Cycle) |
|---|---|---|---|---|
| Vomiting | 1 | 5 | No | - |
| Increased ALT/AST | 3 | 2 | Yes | 4 |
| Pneumonia | 3 | 2 | Yes | 9 |
| Diarrhea | 3 | 3 | Yes | 3 |
| Pneumonia | 3 | 2 | Yes | 4 |
| Upper respiratory tract infection | 3 | 2 | Yes | 4 |
| Diarrhea | 3 | 7 | Yes | 12 |
| Upper respiratory tract infection | 2 | 3 | Yes | 5 |
| Increased ALT/AST | 3 | 2 | No | - |
| Diarrhea | 3 | 3 | Yes | 4 |
| Neutropenia | 3 | 2 | No | - |
| Upper respiratory tract infection | 3 | 4 | Yes | 6 |
| Rash | 3 | 22 | Yes | 40 |
| Pneumonia | 3 | 2 | Yes | 3 |
| Upper respiratory tract infection | 2 | 15 | Yes | 38 |
| Anemia | 2 | 14 | No | - |
| Upper respiratory tract infection | 2 | 3 | Yes | 33 |
| Increased ALT/AST | 2 | 2 | Yes | 5 |
| Increased ALT/AST | 2 | 2 | Yes | 4 |
| Diarrhea | 3 | 4 | Yes | 7 |
| Rash | 2 | 5 | No | - |
| Increased ALT/AST | 2 | 5 | Yes | 6 |
| Increased ALT/AST | 3 | 2 | Yes | 3 |
| Diarrhea | 3 | 3 | No | - |
| Mucositis | 3 | 2 | No | - |
ALT—alanine aminotransferase; AST—aspartate aminotransferase.