Figure 2.

Schematic illustration of in vivo experiments. In experiment 1 (A), the optimal time point for cytoreductive primary tumor resection was determined. In experiment 2 (B), mice were randomized into a group that underwent primary tumor resection and a group that underwent a sham operation. The mice were further followed up to analyze the effect of primary tumor resection on disease progression and survival. PSA = prostate-specific antigen.