TABLE 1C.
Main characteristics of systematic reviews dealing with the association between periodontitis and depression: results and conclusion remarks.
| Results_meta-analysis | |||||
|---|---|---|---|---|---|
| References | Cross-sectional studies | Case-control studies | Global | Amstar-2 | Conclusion comment |
| Araújo et al. (48) |
n (s) = 7/n (p) = 6,125 OR = 1.03 (95% CI: 0.75–1.41); I2 = 60.34% |
Meta-analysis not done due to high heterogeneity (87.48%) 3 studies reported positive significant association between depression and clinical parameters for periodontitis, while 3 studies showed no association. |
/ | High confidence | No association found when only cross-sectional studies are included in the meta-analysis |
| Liu et al. (49) |
n (s) =7/n (p) = 5,997 OR = 1.03 (95% CI: 0.75–1.41) |
n (s) = 6/n (p) = 994 OR = 3.72 (95% CI: 2.45–9.52) |
n (s) = 14/n (p) = 7,139 OR = 1.61 (95% CI: 1.16–2.23) I2 = 84.3%, p < 0.001 |
Moderate confidence | When case-control studies are included in the analysis, a significant global association is found between periodontitis and depression |
| Zheng et al. (50) |
n (s) = 17/n (p) = 23,838 OR = 1.08 (95% CI: 0.88–1.32); I2 = 71.8%, p < 0.001 |
n (s) = 8/n (p) = 1,245 OR = 1.70 (95% CI: 1.01–2.83); I2 = 72.5%, p = 0.001 |
n (s) = 25/n (p) = 25,083 OR = 1.16 (95% CI: 0.99–1.35) I2 = 70.9%, p < 0.001 Severe periodontitis subgroup: OR = 1.427 (95% CI: 1.053–1.933) |
Moderate confidence | With a larger sample size, a significant association is found between periodontitis and depression, only when case-control studies are included in the analysis |
OR, odds ratio; CI, confidence interval; PD, probing depth; CAL, clinical attachment level; BOP, bleeding on probing; GI, gingival index; PI, plaque index; CI, calculus index; AAP, American Academy of periodontology; CDC, Centers for Disease Control and Prevention; s, studies; p, patients.