Table 2.
Protein, protein class, and subclass of lung cancer exosomes.
| Protein Class a | Protein Subclass a | Protein | Top100 c |
|---|---|---|---|
| Calcium-binding protein | - | ANXA1 | Yes |
| ANXA2 | Yes | ||
| ANXA3 | No | ||
| ANXA5 | Yes | ||
| ANXA6 | Yes | ||
| ANXA11 | Yes | ||
| Cell adhesion molecule | integrin | ITGA3 | No |
| ITGB1 | Yes | ||
| - | MUC1 | No | |
| Chaperone | Hsp90 family chaperone | HSP90/HSP90AA1 | Yes |
| Chromatin/chromatin-binding, or -regulatory protein | histone | HIST1H4A/H4C1 | Yes |
| Cytoskeletal protein | microtubule or microtubule-binding cytoskeletal protein | GCC2 | No |
| actin binding motor protein (actin or actin-binding cytoskeletal protein) | TPM3 | No | |
| Defense/immunity protein | immunoglobulin receptor superfamily | CD86 | No |
| PD-L1/CD274 | No | ||
| Tim-3/TIM3 | No | ||
| major histocompatibility complex protein | MHC-I | No | |
| MHC-II | No | ||
| Extracellular matrix protein | - | Galectin-9 | No |
| MUC5B | No | ||
| Intercellular signal molecule | - | ANGPTL4 | No |
| growth factor | AREG | No | |
| TGF-β/TGFB1 | No | ||
| Membrane traffic protein | - | ALIX/PDCD6IP | Yes |
| Metabolite interconversion enzyme | oxidoreductase | HTATIP2 | No |
| phosphatase (hydrolase) | PLAP/ALPP | No | |
| Protein modifying enzyme | serine protease (protease) | HGF | No |
| cysteine protease (protease) | TNFAIP3 | No | |
| ubiquitin-protein ligase | HUWE1 | No | |
| TSG101 | Yes | ||
| Protein-binding activity modulator | protease inhibitor | AHSG | No |
| GTPase-activating protein (G-protein modulator) | IQGAP/IQGAP1 | No d | |
| NPRL2 | No | ||
| small GTPase (G-protein) | RALA | No d | |
| RHOV | No | ||
| Transfer/carrier protein | apolipoprotein | CD91/LRP1 | No |
| Transmembrane signal receptor | - | EGFR | No |
| Transporter | - | AQP5 | No |
| NA b | NA b | CD9, CD63, CD81, FLOT1, HSC70/HSPA8, HSP70, Hsp72, THBS1 | Yes |
| A1AG1/ORM1, BAGE, CD5L, CD54/ICAM1, CD151, CD171/L1CAM, CEACAM1, CTNNB1, ECM1, EpCam, GRB2, HRS/HGS, HSP60, IL-10/IL10, JAK1, LBP, LRG1, NY-ESO-1/ESO1/CTAG1B, PROM1, SRC, SRGN, TSPAN8, VIM | No |
a Protein class and subclass were based on PANTHER classification system (http://www.pantherdb.org/) (accessed on 27 December 2021). b NA: Protein class and subclass were not available for the list of proteins. c Yes/No: Protein found in top100 proteins of ExoCarta (http://www.exocarta.org/) (accessed on 27 December 2021) or not. d Protein not found in top100 proteins of ExoCarta but found in top100 EV proteins of Vesiclepedia (http://www.microvesicles.org/) (accessed on 27 December 2021).