Table 1.
Clinical and pathological characteristics of RB patients stratified by TFF1 expression in aqueous humor. NA: not available, n: number in each group, N: total number. * Kruskal–Wallis rank sum p-value.
| TFF1 Expressed n (%) | TFF1 Not Expressed n (%) | N | p-Value * | |
|---|---|---|---|---|
| Patients | 9 (60) | 6 (40) | 15 | |
| Sex | 1 | |||
| Female | 6 (67) | 4 (67) | 10 | |
| Male | 3 (33) | 2 (33) | 5 | |
| RB1 germline mutations | 0.88 | |||
| Yes | 1 (11) | 0 (0) | 1 | |
| No | 5 (56) | 2 (33) | 7 | |
| NA | 3 (33) | 4 (67) | 7 | |
| Laterality | 0.79 | |||
| Unilateral | 7 (78) | 5 (83) | 12 | |
| Bilateral | 2 (22) | 1 (17) | 3 | |
| Age at diagnosis | 0.47 | |||
| <18 month | 4 (45) | 3 (50) | 7 | |
| 18–36 month | 3 (33) | 3 (50) | 6 | |
| >36 month | 2 (22) | 0 (0) | 2 | |
| Tumor volume | 0.26 | |||
| <2 cm3 | 2 (22) | 1 (17) | 3 | |
| 2–5 cm3 | 6 (67) | 2 (33) | 8 | |
| >5 cm3 | 1 (11) | 3 (50) | 4 | |
| Optic nerve invasion | 0.89 | |||
| None | 1 (11) | 1 (17) | 2 | |
| Pre-laminar | 7 (78) | 4 (67) | 11 | |
| Post-laminar | 1 (11) | 1 (17) | 2 | |
| Choroid invasion | 0.30 | |||
| None | 8 (89) | 4 (67) | 12 | |
| Invasion | 1 (11) | 2 (33) | 3 | |
| Pre enucleation MRI | 0.76 | |||
| Choroid invasion | 2 (22) | 2 (33) | 4 | |
| Optic nerve invasion | 3 (33) | 3 (50) | 6 |