Figure 2.

Overview of metabolic pathways most consistently reported to be altered in PCa in the multi-omics studies reviewed in this article, including: hexosamine biosynthesis pathway [64,65], purine metabolism [61], fatty acid synthesis [58,59,63], amino acid metabolism [61], TCA cycle [60,62], glutathione metabolism [58], glutaminolysis [62,66] and polyamine metabolism [58,63]. Thick lines highlight the metabolic pathways found to be upregulated in PCa tumors when compared with benign prostate tissue. References corresponding to the multi-omic studies describing alterations in each metabolic pathway are included. α-KG: alpha-ketoglutarate, Fructose-6P: fructose-6-phosphate, Glucosamine-6P: glucosamine-6-phosphate, Glucose-6P: glucose-6-phosphate, IMP: inosine monophosphate, PRPP: phosphoribosyl diphosphate, Ribose-5P: ribose-5-phosphate.