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. 2022 Jan 18;14(3):476. doi: 10.3390/cancers14030476

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Cutaneous adenoid cystic carcinoma (ACC): (a) ACC is arranged in various cribriform aggregates and ductal structures (HPS, ×100); (b) periodic acid-Schiff (PAS) reaction highlights entrapped basement membrane material within aggregates (HPS, ×200); (c) c-KIT (CD117, ×200) immunohistochemistry stains luminal cells; (d) immunostaining for p63 highlights outer myoepithelial cells with a discontinuous pattern (×200); (e) SOX10 immunohistochemistry is intensely and diffusely positive in the nuclei of ACC (×200); (f) fluorescence in situ hybridization (FISH, break-apart probe) demonstrates a clonal rearrangement of MYB in neoplastic cells (×1000).