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. 2022 Jan 18;14(3):476. doi: 10.3390/cancers14030476

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Cutaneous syncytial myoepithelioma: (a) this variant of myoepithelioma occurs predominantly in the superficial dermis (×25); (b) epithelioid and plasmacytoid cells are arranged in sheets with little or no intervening stroma (×200); (c) AE1/AE3 immunohistochemistry is most often negative or stains only scattered isolated cells (×100); (d) PS100 (×100) and (e) EMA immunohistochemistry stains various populations of cells (×100); (f) fluorescence in situ hybridization (FISH, break-apart) demonstrates clonal rearrangement of EWSR1 gene (×1000).