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Cutaneous secretory carcinoma: (a) circumscribed intradermal neoplastic proliferation (×10); (b) intracytoplasmic secretory vacuoles and extracellular bubbly eosinophilic secretions (×100); (c) nuclear staining with panTRK immunohistochemistry is highly suggestive of ETV6::NTRK3 fusion (×200); (d) fluorescence in situ hybridization (FISH, break-apart) demonstrates clonal and balanced rearrangement of NTRK3 gene (×1000).
