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miRNAs in the bone metastatic environment. The bone microenvironment consists of several cell types, including osteoblasts, osteoclasts, stromal cells, and endothelial cells, that orchestrate the tightly regulated bone metabolism. Cancer- and bone-cell-derived miRNAs can either promote or suppress metastatic outgrowth of tumor cells within the bone. The figure depicts the role of miRNAs in breast cancer bone metastasis and groups them according to their influence on tumor growth.
