Table 1.
miRNAs involved in breast cancer bone metastasis.
| MicroRNA | Target | Effect on Bone Metastasis | Reference |
|---|---|---|---|
| miR-10b | Promoting | [56,93,94] | |
| miR-1976 | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma (PIK3CG) | Inhibiting | [60] |
| miR-429 | V-crk sarcoma virus CT10 oncogene homolog-like (CrkL) and Matrix metalloprotease 9 (MMP-9) | Inhibiting | [62] [32,46,47,48] |
| miR-30 family | Osteomimicry genes e.g., Cadherin 11 (CDH11) and Integrin Alpha 5 (ITGA5), Interleukins | Inhibiting | [63] |
| miR-205 | Inhibiting | [64] | |
| miR-143 | Mitogen-activated protein kinase 3 (MAPK3) | Inhibiting | [65] |
| miR-20a-5p | SRC Kinase Signaling Inhibitor 1 (SRCIN1) | Promoting | [66] |
| miR-34a-5p | Met | Inhibiting | [67] |
| miR-135 | Runt-related transcription factor 2 (Runx2) | Inhibiting | [69] |
| miR-203 | Runx2 | Inhibiting | [69,93] |
| miR-124 | Interleukin-11 (IL-11) | Inhibiting | [46] |
| miR-19a | Phosphatase and Tensin homolog (PTEN) | Promoting | [72] |
| miR-141 | Microphthalmia-associated transcription factor (Mitf) | Inhibiting | [73] |
| miR-219 | Mitf, TNF receptor associated factor (Traf-6) | Inhibiting | [73] |
| miR-204, miR-211, and miR-379 | IL-11 | Inhibiting | [85] |
| miR-218 | Dickkopf-related protein 2 (DKK2), Secreted frizzled-related protein 2 (sFRP2), Sost | Promoting | [32,58] |
| miR-192 | IL-8, Intercellular Adhesion Molecule (ICAM) and C-X-C Motif Chemokine Ligand 1 (CXCL1) | Inhibiting | [31] |