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. 2022 Jan 28;13:828373. doi: 10.3389/fgene.2022.828373

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Copyright © 2022 Jiang, Yang, Gao, Liu, Feng, Ye and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differentially expressed RABs, genetic alteration, and sequence alignment of the RABs in colorectal cancer. (A) 7 RABs (RAB10, RAB11A, RAB15, RAB17, RAB19, RAB20, and RAB25) were significantly upregulated in tumor tissues. (B) 6 RABs (RAB6B, RAB9B, RAB12, RAB23, RAB31, and RAB34) were significantly downregulated in tumor tissues. Red and grey bar represents tumor and normal tissues, respectively. Tumor tissues (COAD: n = 275, READ: n = 92) and normal tissues (COAD: n = 349, READ: n = 318). (C) Genetic alterations frequency of each RABs in 2544 CRC patients. (D) Sequence alignment of the RABs. (E) Phylogenetic tree of the maximum likelihood analysis. ^** p < .01.