TABLE 5.

Univariate and Multivariate Cox Regression Analysis for PFS and OS

	PFS		OS
Parameter	Hazard ratio	P	Hazard ratio	P
Univariate Cox regression analysis
Age	1.1 (1.0–1.1)	0.06	1.1 (1.0–1.1)	0.006
Maximum diameter of primary tumor	1.0 (0.8–1.4)	0.9	1.1 (1.0–1.1)	0.6
Histologic grade		0.8		0.3
I–II	1		1
III	0.9 (0.3–3.0)		0.6 (0.2–1.7)
Lymph-vascular space invasion	2.3 (0.9–6.1)	0.08	3.0 (1.1–7.9)	0.03
Depth of stromal invasion	1.0 (0.9–1.2)	0.4	1.1 (0.9–1.2)	0.4
Resection margin status		0.6		0.4
R0	1		1
R1	2.5 (0.3–18.7)		3.3 (0.4–25.3)
VIN	1.9 (0.2–21.4)		2.5 (0.2–27.4)
Metastatic lymph nodes*	2.1 (0.7–5.9)	0.2	3.0 (1.0–9.2)	0.05
Bilateral metastatic lymph nodes	3.0 (1.2–7.6)	0.02	2.7 (1.0–6.8)	0.04
Number of metastatic lymph nodes*	1.3 (1.0–1.5)	0.02	1.3 (1.0–1.5)	0.03
Extracapsular invasion of metastatic lymph nodes	5.3 (2.1–13.7)	<0.0001	4.2 (1.6–10.6)	0.003
FIGO stage		0.4		0.1
IB	1		1
II	0.6 (0.1–3.9)		0.7 (0.01–5.0)
III	0.3 (0.06–1.5)		0.4 (0.05–2.6)
IVA	0.8 (0.2–3.0)		1.7 (0.4–7.6)
Radiomic feature
SUVmax	1.0 (0.9–1.2)	0.6	1.0 (0.9–1.1)	0.6
Local entropy	1.7 (0.03–99.1)	0.8	0.6 (0–33.2)	0.8
3D maximum diameter	1.0 (1.0–1.0)	0.5	1.0 (1.0–1.0)	0.8
Moran’s I	1.3 (1.0–1.6)	0.06	1.3 (1.0–1.7)	0.03
Multivariate Cox regression analysis
Iterative forward selection
Extracapsular invasion	9.5 (3.1–28.6)	<0.0001	6.5 (2.3–18.4)	<0.0001
Moran’s I	1.6 (1.2–2.3)	0.03	1.5 (1.1–2.1)	0.009
Iterative backward selection
Extracapsular invasion	9.5 (3.1–28.6)	0.0001	4.3 (1.4–12.6)	0.009
Moran’s I	1.6 (1.2–2.3)	0.03	1.4 (1.1–2.0)	0.02

^*Metastatic lymph nodes indicates patients with metastatic lymph nodes; number of metastatic lymph nodes is the number of metastatic lymph nodes per patient.

R0 = no tumor; R1 = microscopic tumor; VIN = vulvar intraepithelial neoplasia; FIGO = International Federation of Gynecology and Obstetrics.

Data in parentheses are 95% confidence intervals.