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. 2021 Feb 19;2(2):zqab007. doi: 10.1093/function/zqab007

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© The Author(s) 2021. Published by Oxford University Press on behalf of American Physiological Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — NaHS Potentiates the Current of All Tested ASIC Isoforms. Current traces and data were obtained by whole-cell patch-clamp at −60 mV of CHO cells transfected with the indicated ASIC isoforms. The indicated time points are relative to the 40-s application of 1 mM NaHS. All quantified currents had been normalized to that induced by acid before the NaHS treatment (at −3 and −6 min). The statistical significance in (B), (D), (F), and (G) is based in each case on a comparison between treatment and control over the period 0–60 min by one-way ANOVA test and Dunnett’s post hoc test; ***P < 0.001. (A) Representative rat ASIC1b current traces, induced by acidification to pH 6.3 at different time points, as indicated. (B) Time course of pH 6.3-induced peak ASIC1b current amplitudes measured without (control, black symbols) or with a 40-s exposure to 1 mM NaHS as indicated (treatment, red symbols), n = 5. (C) Representative human ASIC2a current traces, induced by acidification to pH 5.0. (D) Time course of pH 5.0-induced ASIC2a peak current amplitudes measured without (control, black symbols) or with a 40-s exposure to 1mM NaHS as indicated (treatment, red symbols), n = 5–6. (E) Representative rat ASIC3 current traces, induced by acidification to pH 6.8 at different time points, as indicated. (F) Time course of pH 6.8-induced ASIC3 peak current amplitudes measured without (black symbols) or with a 40-s exposure to 1 mM NaHS as indicated (red symbols), n = 5–6. (G) Time course of pH 6.8-induced ASIC3 sustained current amplitudes measured without (black symbols) or with a 40-s exposure to 1 mM NaHS (green symbols) as indicated, n = 5–6.