Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 28;9(1):420–430. doi: 10.1093/emph/eoab036

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021. Published by Oxford University Press on behalf of the Foundation for Evolution, Medicine, and Public Health.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 2. — Time-dependent upregulation of gene regulatory pathways during dolphin breath holding. (A) Gene regulatory network formed by the time-dependent increases in mRNAs from baseline to 3 and 4.5 min. Fold changes for each gene over time are indicated by darker red and larger nodes. (B) Network analysis of genes within a co-expression network with increased expression over time. (C) Top genes with increased expression are sorted by their network analysis parameters. (D) GeneMANIA-based transcription factor inference pinpoints GATA and SMAD transcription factor targets within the time-dependent network. (E) MicroRNA enrichment inference based on the time-dependent network. (F) Functional pathway enrichments for the time-dependent gene regulatory network.