FIGURE 1.

Both MRI1 (day 16) and MRI2 (day 30) were performed before IVIg therapy. T1-weighted 3-dimensional volumetric scans were processed with FreeSurfer software via neuGRID platform (https://www.neugrid2.eu). FreeSurfer percentiles were derived from 532 healthy controls (age range, 55–90 y; mean ± SD, 73.59 ± 6.29 y). No gray matter volume loss was detected. However, biomarker variations graph shows that volumes of most subcortical regions, including amygdala, thalami, and basal ganglia, were on average 10% greater at second time point, possibly reflecting greater edema associated with inflammatory process. Cortical regions showed less homogeneous pattern, but overall, mean cortical volumes at the 2 time points were of similar magnitude. Lh = left hemisphere; Rh = right hemisphere; CC = corpus callosum; DC = diencephalon.