Figure 2.

Origin of Centrosome Defects. Centrosome defects include structural and numerical changes. Structural defects include alterations in centriole size, length, or the amount of pericentriolar material, among others. Numerical changes are defined by more than two centrosomes per cell and are referred to as centrosome amplification (CA). Many mechanisms underlie the etiology of centrosomal alterations, these include centriole over-duplication, centriole over-elongation, premature centriole disengagement, de novo centriole formation, PCM fragmentation, and cytokinesis failure.