Table 5.

Methodological qualities of GBE animal studies.

Methodological Quality Scores of Included Preclinical Studies
	1	2	3	4	5	6	7	8	Total
Ward, C. P. et al. (2002) [12]	✔	✔			✔		✔		4
Stackman, R. W. et al. (2003) [14]	✔		✔		✔		✔		4
Gong, Q. H. et al. (2005) [15]	✔	✔		✔	✔		✔		5
Wang, Y. et al. (2006) [16]	✔	✔		✔	✔		✔		5
Gong, Q. H. et al. (2006) [17]	✔	✔		✔	✔		✔		5
Tchantchou, F. et al. (2007) [18]	✔				✔		✔		3
Blecharz-Klin, K. et al. (2009) [19]	✔	✔			✔		✔	✔	5
Hou, Y. et al. (2010) [50]	✔				✔		✔		3
Tian, X. et al. (2012) [21]	✔	✔			✔		✔	✔	5
Tian, X. et al. (2013) [22]	✔	✔			✔		✔		4
Jahanshahi, M. et al. (2013) [23]	✔	✔			✔		✔	✔	5
Zhang, L.-D. et al. (2015) [24]	✔	✔			✔		✔	✔	5
Liu, X. et al. (2015) [25]	✔	✔			✔		✔		3
Wan, W. et al. (2016) [26]	✔				✔		✔	✔	4
Zeng, K. et al. (2018) [27]	✔				✔		✔	✔	4
Verma, S. et al. (2019) [28]	✔				✔		✔	✔	4
Verma, S. et al. (2020) [29]	✔	✔			✔		✔	✔	5
1.Was the article published in a peer-reviewed journal?
2. Were the animals allocated to the treatment group or control group randomly during the experiment?
3. Were the outcomes assessed blindly?
4. Was the dose–response relationship assessed during the experiment?
5. Was the appropriate animal model used in the experiment?
6. Was the necessary sample size calculated to achieve sufficient power?
7. Were the animal welfare regulations complied with during the experiment?
8. Was the study free of any potential conflicts of interest?