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. 2022 Jan 20;11(3):335. doi: 10.3390/cells11030335

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Glial fibrillary acidic protein (GFAP) levels are increased in tissue lysates of Crohn’s disease (CD) patients compared to non-inflammatory bowel disease (non-IBD) controls. (A) Representative Western blot image (converted into a black and white density blot) showing GFAP bands from one CD patient and one non-IBD control, respectively (B) Quantification of the bands after normalizing GFAP levels against the β-actin loading control (C) GFAP protein levels were higher in Peyer’s patches (PP) of 9 out of the 12 CD patients analyzed, compared to lamina propria (LP) (D) GFAP protein levels were lower in PP of 10 out of the 12 non-IBD controls analyzed, compared to LP. Data presented as median and IQR. Mann–Whitney U test was used for comparisons between groups and Wilcoxon matched-pairs signed-rank test for paired data, * p < 0.05.