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. 2022 Jan 20;11(3):335. doi: 10.3390/cells11030335

Figure 4.

Figure 4

Enteric glial cells (EGC) expressing S100 calcium-binding protein β (EGCS100β+) are more prominent in Crohn’s disease (CD) patients. (A) Representative immunofluorescent images of EGCS100β+ in i the lamina propria (LP) of CD patients, ii Peyer’s patches (PP) from CD patients, iii LP of non-inflammatory bowel disease (non-IBD) controls and iv in PP of non-IBD controls. Arrows indicate EGCS100β+ cells. Scale bar 100 μm. (B) Quantification of EGCS100β+ in CD patients and non-IBD controls (C) The distribution of EGCS100β+ in LP and PP of CD patients and non-IBD controls (D) The number of EGCS100β+ was higher in PP of 4 out of the 12 CD patients analyzed, compared to LP (E) The number of EGCS100β+ was lower in PP of 11 out of the 12 non-IBD controls analyzed, compared to LP. Data presented as median and IQR. Mann–Whitney U test was used for comparisons between groups and Wilcoxon matched-pairs signed-rank test for paired data, * p < 0.05, ** p < 0.01.