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Lactate supplementation facilitated transcriptional elongation through enhanced histone lactylation. (A–C) Read density plot of H3K18la (A), H3K4me3 (B), and RNA PolII (C) signals at gene bodies and promoters of upregulated genes (upper panel), and corresponding heatmap at gene bodies and promoters (3 kb flanking TSSs) of upregulated genes (lower panel). (D) Schematic diagram of the mechanism by which lactate promotes expression of germline/ZGA genes.
