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. 2022 Feb 2;11(3):516. doi: 10.3390/cells11030516

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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EVs contained HSP70-associated PQC system components. (A–C) Representative WB analysis of cellular, LVs and SVs samples derived from NSC-34 cells grown in basal conditions showed the presence of HSP70, BAG3, HSPB8 and MAP1LC3B proteins. (A) WB showed HSP70 in all samples, whereas its co-chaperone BAG1 was not detected in EVs. (B) HSP70, BAG3 and its partner HSPB8 were present in all samples. (C) WB analysis showed that cells are enriched in the MAP1LC3B-I form, whereas EVs contained both the MAP1LC3B-I and its lipidated form, MAP1LC3B-II.