Figure 1.

Structure of the CBL, CBL-b and CBL-c proteins with the relative functional domains and main phosphorylation sites. CBL and CBL-b are structurally related while CBL-c lacks the C terminal domain, including the UBA region and the proline and tyrosine rich region, mediating the binding to the SH2 and SH3 domain-containing proteins. The highly conserved N terminal region with the TKB, Linker and RF domains is crucial in the regulation of receptor and non-receptor tyrosine kinase activity.