Table 3.
Dynamics of the RAS conversion at different timepoints.
| Ras Mutation Tissue/Plasma Baseline | Timing of First Ras Conversion (Months) | Response at First Ras Conversion | Ras Status at Serial Timepoints (* PD) | |||
|---|---|---|---|---|---|---|
| 3 Mo | 6 Mo | 9 Mo | 12 Mo | |||
| KRAS G12V | 3 | SD | wild-type | wild-type | wild-type | wild-type * |
| KRAS G12V | 9 | PD | KRAS G12V | KRAS G12V | wild-type * | wild type |
| KRAS G12V | 9 | PD | KRAS G12V | KRAS G12V | wild-type * | wild-type |
| KRAS G12V | 3 | PR | wild-type | wild-type | wild-type | wild-type |
| KRAS G12V | 3 | PR | wild-type | wild-type | wild-type | wild-type * |
| KRAS G12V | 3 | PR | wild-type | wild-type | wild-type | wild-type |
| KRAS G12V | 9 | PR | KRAS G12V | KRAS G12V | wild-type | wild-type |
| KRAS G12V | 6 | PR | KRAS G12V | wild-type | wild-type | wild-type * |
| KRAS G12C | 6 | PR | KRAS G12C | wild-type | wild-type | wild-type * |
| KRAS G12C | 3 | PR | wild-type | wild-type | wild-type | wild-type * |
| KRAS G12C | 6 | PR | KRAS G12C | wild-type | wild-type | wild-type |
| KRAS G12C | 12 | PD | KRAS G12C | KRAS G12C | KRAS G12C | wild-type * |
| KRAS G12D | 6 | PD | KRAS G12D | wild-type * | wild-type | wild type |
| KRAS G12D | 3 | PR | wild-type | wild-type | wild-type | KRAS G12D* |
| KRAS G12D | 6 | SD | KRAS G12D | wild-type | wild-type * | wild-type |
| KRAS G12D | 9 | PD | KRAS G12D | KRAS G12D | wild-type * | wild-type |
| KRAS G12D | 3 | PR | wild-type | wild-type | wild-type | wild type * |
| KRAS G12D | 6 | PR | KRAS G12D | wild-type | wild-type | wild-type |
| KRAS G12D | 3 | SD | wild-type | wild-type | wild-type * | KRAS Q61H |
| KRAS G12D | 6 | SD | G12D | wild-type | wild-type | wild type * |
| KRAS G12D | 9 | PD | KRAS G12D | KRAS G12D | wild-type * | wild-type |
| KRAS G12D | 9 | PD | KRAS G12D | KRAS G12D | wild-type * | wild-type |
| KRAS G12D | 9 | SD | KRAS G12D | KRAS G12D | wild-type | wild type |
| KRAS G12D | 12 | PD | KRAS G12D | KRAS G12D | KRAS G12D | wild type * |
| KRAS G12D | 3 | SD | wild-type | wild-type | wild-type | KRAS Q61K* |
| KRAS G12A | 6 | SD | KRAS G12A | wild-type | wild-type * | wild-type |
| KRAS G12A | 6 | PR | KRAS G12A | wild-type | wild-type | wild-type |
| KRAS G12A | 6 | CR | KRAS G12A | wild-type | wild-type | wild-type |
| KRAS G13D | 3 | PR | wild-type | wild-type | wild-type | KRAS G13D * |
| KRAS G13D | 6 | PR | KRAS G13D | wild-type | wild-type | wild-type |
| KRAS A146T | 3 | PR | wild-type | wild-type | wild-type * | KRAS G12C |
| KRAS A146T | 6 | PD | KRAS A146 | wild-type * | wild-type | wild-type |
| KRAS A146T | 9 | CR | KRAS A146T | KRAS A146T | wild-type | wild type |
| KRAS A146T | 12 | PR | KRASA146P/T/V | KRASA146P/T/V | KRASA146P/T/V | wild-type |
| KRAS Q61K | 3 | PR | wild-type | wild-type | wild-type | wild-type * |
| KRAS Q61K | 6 | SD | KRAS Q61K | wild-type | wild-type * | wild-type |
| KRAS Q61H | 12 | PD | KRAS Q61H | KRAS Q61H | KRAS Q61H | wild type * |
| NRAS G12C | 3 | PR | wild-type | wild-type | wild-type | wild-type * |
| NRAS G12D | 6 | PD | NRAS G12D | wild-type * | wild-type | wild-type |
| NRAS G12D | 3 | SD | wild-type | wild-type | wild-type* | wild type |
| NRAS G12D | 9 | PD | NRAS G12D | NRAS G12D | wild-type * | wild-type |
| NRAS A146T | 3 | SD | wild-type | wild-type * | wild-type | wild-type |
| NRAS Q61R | 3 | SD | wild-type | wild-type * | wild-type | wild-type |
Mo: months; * PD: progressive disease; SD: stable disease; PR: partial response; CR: complete response.