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. 2022 Feb 4;11(3):542. doi: 10.3390/cells11030542

Figure 1.

Figure 1

Phenotypic and functional alterations in Unconventional T Cells and ILC in SARS-CoV-2 infection. (A) The host response of NKT cells to SARS-CoV-2 infection is illustrated with modulation of surface receptors distinguished in circulating or recruited in lung tissue as well as the phenotypic subsets divided for symptoms in moderate and severe subgroups. (B) Specific features of MAIT cells associated with moderate and severe COVID-19 and the phenotypic subsets revealed. (C) The host response of γδ T cells to SARS-CoV-2 infection is illustrated with modulation of surface receptors in circulating and infiltrating γδ T cells as well as the phenotypic subsets divided for symptoms in moderate and severe subgroups of γδ T cells subsets (Vδ1 and Vδ2 T cells). Moreover, phenotypic subsets of γδ T cells were evaluated in severe patients. (D) ILC precursor (ILCp), ILC2 and ILC3 responses were illustrated with expression markers of moderate and severe patients and from ILC in blood and in lung tissue.