Figure 7.

Gene expression (a) and DNA methylation (b) of chromatin states in the fetal and adult brain. “Overlap” genes do not change their state between fetal and adult brain. Chromatin states refer to active promoters (TssA), transcribed genes (Tx), weak active enhancer and enhancer-like states (Enh, EnhG, EnhP), zinc finger proteins (ZNF), quiescent (Quies), heterochromatin (Het), heterochromatin repeats (HetRpts), poised promoters (TssP), repressed polycomb states (RepPC, weak: RepPCWk) and were taken from [30]. The profiles can be divided into three major groups, referring to repressed, active/poised genes and heterochromatin/enhancers. The boxplots in the right part of (a,b) show profiles of selected groups of chromatin states across the age strata in GSZ (gene set Z-) score. (c) Correlation plots between expression and methylation for selected chromatin states (columns) and brain developmental stages (rows) indicate changing slopes and directions of the trajectories. (d) Schematic illustration of the expression (red) and methylation (blue) profiles across age. The red arrows indicate expected (nominal) expression in the respective states, e.g., low expression in repressed and high expression in transcribed states. (e) Number of genes in the different states. The largest fraction of genes in the fetal brain only refer to active states (TssA) while genes in adult brain (only and overlap) are mostly found in the other states.