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. 2022 Jan 21;11(3):362. doi: 10.3390/cells11030362

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Figure A11 — Maps and profiles of brain-related gene sets taken from [93,94,119]. Stemness sets were taken from single cell transcriptomics [93]. They resemble courses of PRC2-repressed genes that govern stemness properties. Senescence genes were selected by hypermethylation criteria and virtually anticorrelate with expression [94]. Senescence genes and genes encoding GPCR accumulate in the IV-area of the expression map thus reflecting invariant gene expression upon aging. Single cell profiles of astrocytes and oligodendrocytes show mirror symmetric expression profiles with a minimum/maximum for children and adolescents. Both cell types seem to hypermethylate with age. Schizophrenia related sets taken from [119] resemble that of astrocytes.