Figure A13.

Expression and methylation characteristics of gene sets of different functional context related to schizophrenia taken from [121,122,123]. In healthy subjects, inflammatory processes are activated during the first years of life and then decreased and became overexpressed in oldness (regulation of inflammatory response). U-shaped changes upon aging are shown for secretion of neurotransmission in brain disorders and healthy controls as well. The same applied for neuronal death related processes with the maximum at childhood. U-shaped changes are common for presynapse assembly disrupted in mental and behavioral disorders. No significant changes depending on age in case of processes involved in the innate immune response in healthy subjects are shown while several studies indicated altered innate immunity both in psychiatric disorders and ALC [124,125]. The main player of immunity, the compliment system suggested association with SCZ implicated a new risk factor for disease development [122]. On the other hand, evidence suggested contribution of abnormal apoptosis in brain and behavioral disorder [126]. Interestingly, cytokine and chemokine network implicated in the abovementioned disorders seems to be constantly expressed regardless the age [121,127,128]. In particular, a strong contribution of chemo-cytokine network to SCZ development indicated [121,123,129]. In contrast, genes enrolled in long-term neuronal synaptic plasticity regulation are expressed almost constantly over the time. Despite alterations in neurodevelopment are involved in mental disorders, genes underlying these processes seem to have no age-dependence.