Table A1.
Functional context of expression spots.
| Spot | Notation | Up/DN | Top Genes (a) | Biological Function/Enriched Gene Sets (b) |
|---|---|---|---|---|
| A | Newborn_up; “development” | Newborn/Teenager, Adult, Late Adult | SOX11, DCX, CRMP1, TENM1, STMN2, KIF21B, DPYSL3, RPL12, TUBB, JPT1 | BP_nervous-system-development, BP_cell-adhesion, MEISSNER_BRAIN_HCP_ WITH_H3K4ME3_ AND_H3K27ME3, Benporath_ES-with_H3K27me3, VAQUERIZAS_Fetal brain_TF, Hebenstreit_low-expression-TFs, Verhaak_Glioblastoma_proneural |
| B | Baby_up; “synaptic transmission” | Baby, Infant, Teenager/Late Adult | SCAMP1, TBC1D9, CNTN1, PRKCB, SUMO3, RAB6A, FKBP1A, FYTTD1, MYT1L, NDFIP1 | BP_chemical-synaptic-transmission, LU_AGING_BRAIN_DN, REACTOME_NEURONAL_ SYSTEM, repressed chromatin states fetal brain, Reifenberger_Glioblastoma_CL&PNwt, Chaussabel_cytoskeleton, GO_CC_Synapse |
| C | Teenager_up; “transport” | Infant, Teenager/Late Adult | PCMT1, GHITM, LMBR1, C8orf46, SKP1, TRIM23, OXR1, RGS4, IDH3A, GABARAPL1 | BP_transport, BLALOCK_ALZHEIMERS_ DISEASE_ DN, Reifenberger_Glioblastoma_CL&PNwt, KIM_Myc-targets, LU_AGING_BRAIN_DN |
| D | Infant_up; “signal transduc-tion” | Infant, Teenager/Late Adult | NRGN, ARPP19, NGEF, ARHGDIB, OLFM1, PIN1, JCAD, ATG101, LRPAP1, YJEFN3 | BP_signal-transduction, CC_plasma-membrane, WILLSCHER_GBM_Verhaak−CL & MES_up, Lembcke_CIMP_H, Verhaak_Glioblastoma-Mesenchymal |
| E | Adult_up; “nervous system” | Adult/Newborn, Baby | ITPR1, RCAN2, KCNAB2, BCL2L2, CABP1, STEAP2, ITPR1, RIMS3, EIF5A2, ATP6V1E1 | Wirth_nervous-system; Blalock_Alzheimer-disease-DN; KIM_ALL_DISORDERS_OLIGODENDROCYTE_ NUMBER_CORR_UP, Glioblastoma_DN; CC_mylin-sheath |
| F | Late Adult_up1; “lipid metabolism” | Adult, Late Adult/ Baby, Infant |
PIP4K2A, USP54, HSPA2, GPRC5B, PLEKHB1, PLEKHH1, ANP32B, CLDND1, MAN2A1, TMEM144 | BP_lipid-metabolic process; BP_myelination, ASTON_MAJOR_DEPRESSIVE_DISORDER_DN, BLALOCK_ALZHEIMERS_DISEASE_UP, LU_AGING_BRAIN_UP, MEISSNER_BRAIN_ HCP_ WITH_H3K4ME3_AND_H3K27ME3, OL versus OPC |
| G | Late Adult_up2; “transcription” | Late Adult/ Baby, Infant, Teenager |
DTNA, ADD3, PLPP3, BMPR1B, PLPP3, RHOBTB3, ADD3, ALDH9A1, METTL7A, ACSS1 | BP_positive-regulation of-transcription, LU_AGING_BRAIN_UP, BLALOCK_ALZHEIMERS_DISEASE_UP, Lein_astrocyte-markers, Verhaak_Glioblastoma-classical, Chaussabel_Interferon-inducable |
(a) Top 10 genes with largest correlation coefficient of their expression profile with spot profile (r > 0.9). See Supplementary Materials, Supplementary Table S1, for full gene list, gene names and further details. (b) Gene sets were implemented in oposSOM ([27,28] and references cited therein). Enrichment was calculated using Fisher’s exact test [51]. Only gene sets with enrichment p < 10−6 were considered.