Table A2.
Functional context of methylation spots.
| Spot | Notation | Up/DN | Top Genes (a) | Biological Function/Enriched Gene Sets (b) |
|---|---|---|---|---|
| Am | Fetal_up; | Newborn/Teenager, Adult, Late Adult | MPG, IPO8, WFDC3, DNTTIP1, GOT2, RARRES3, SSRP1, ABHD14B, FAM162A, CCDC58 | Horvath_aging-genes_DN, Hallmark_Interferon-gamma/alpha_response, Lembcke_CIMP_hypermeth_UP, Hopp_IDH-meth-DN |
| Bm | Baby_up; | Baby | NUP98, ZDHHC4, HLTF, EAPP, RNASEH2A, TKFC, TMEM175, GPS2, HYAL3, CCNB1 | Lembcke_CIMP_hypermeth_DN, |
| Cm | Infant; | Infant | SYF2, ADAM17, PHC1, SECISBP2, MTDH, CHPT1, ZRANB2, USP49, MRPL51 | No set enriched |
| Dm | Infant_up; late-adult_up | Infant, Late Adult | LAD1, HESX1, PYY, DKK4, SEL1L3, TP73, FOXD4L1, PIP5KL1, MYL4, WDR86 | Hopp_Fetus_methylation_UP, CC-nucleus, BP_RNA-binding |
| Em | Late adult | Adult/Newborn, Baby | SALL4, GPR17, MIXL1, SYTL1, CFTR, NRK, IL18, DCT, SYNE2, CCDC69 | Hopp_IDH-meth_UP, Benporath_ES-H3K27me3, Benporath_PRC2-targets |
(a) Top 10 genes with largest correlation coefficient of their methylation profile with spot profile (r > 0.9). See Supplementary Materia, Supplementary Table S2 for full gene list, gene names and further details. (b) Gene sets were implemented in oposSOM ([27,28] and references cited therein). Enrichment was calculated using Fisher’s exact test [104]. Only gene sets with enrichment p < 10−6 were considered.