Table 1.
LncRNA: miRNA interactions in prostate cancer and their phenotypic implications.
| LncRNA | Interacting miRNA | Target mRNA | Expression in PCa | Functions in PCa |
|---|---|---|---|---|
| SNHG14 | miR-5590-3p [211] | YY1 | Increase | Promote cell proliferation, invasion, and repress apoptosis |
| TUG1 | miR-496 [76] | Wnt | Increase | Promote cell proliferation, migration, invasion, colony survival fraction and repress apoptosis |
| miR-139-5p/miR-26a [75] | SMC1A | |||
| SOX2-OT | miR-425-5p [212] | HMGB3 | Increase | Promote cell proliferation, migration, cancer metastasis, and active the Wnt/b-catenin signaling pathway |
| miR-369-3p [213] | CFL2 | |||
| SNHG1 | miR-377-3p [214] | AKT2 | Increase | Promote cell viability, growth, cell cycle progression and |
| miR-199a-3p [215] | CDK7 | suppress cell apoptosis | ||
| UCA1 | miR-143/miR-204 | MYO6/Bcl2 | Increase | Promote cell growth, invasion, and suppress apoptosis |
| miR-184 [66,68,69,70,71] | Sirt1/CXRC4 | |||
| ATF2 | ||||
| SNHG12 | miR-195 [86,87] | CCNE1 | Increase | Promote cell proliferation, invasion, migration, viability; Suppress apoptosis and autophagy; activate PI3K/AKT/mTOR pathway and Wnt/b signaling pathway |
| miR-133b [88] | ||||
| NEAT1 | miR-34a/miR-204 [63] | RET/ACSL4 | Increase | Promote cell growth and invasion; potential prognostic biomarker |
| miR-98 [64] | HMGA2 | |||
| DANCR | miR-34a [216] | JAG1 | Increase | Promote cell proliferation, resistant to apoptosis; Silence of DANCR improved docetaxel and paclitaxel efficacy |
| miR-135a [217] | ||||
| MALAT1 | miR-1 [57,58] | KRAS/CORO1C | Increase | Promote cell proliferation, migration, invasion, EMT and resistant to apoptosis; promote tumor growth in vivo |
| miR-145/miR-320B [59,60] | AKAP12/AR | |||
| SNHG7 | miR-324-3p [218] | WNT2B | Increase | Promote proliferation, migration, invasion, and EMT; induce cell cycle arrest; silence SNHG7 inhibit tumor growth in vivo |
| miR-503 [219] | CyclinD1 | |||
| LOXL1-AS1 | miR-let-7a-5p [220] | EGFR | Increase | Promote cell proliferation, migration, cell cycle progression; suppress apoptosis; promote tumor growth in vivo |
| miR-541-3p [221] | CCND1 | |||
| PCA3 | miR-1261 [79] | PRKD3 | Increase | Promote proliferation, migration, invasion, xenografts growth; inhibit apoptosis and autophagy |
| miR-218-5p [84] | HMGB1 | |||
| HOTAIR | miR-520b [222] | FGFR1 | Increase | Promote cell proliferation, migration and invasion; reasonable biomarker for PCa bone metastasis |
| PVT1 | miR-186/miR-146 [223,224] | Twist1 | Increase | Promote EMT and cell invasion, and repress cell apoptosis |
| LINC00473 | miR-195-5p [225] | SEPT2 | Increase | Promote cell proliferation via JAK-STAT3 signaling pathway |
| SNHG17 | miR-144 [226] | CD51 | Increase | Promote cell proliferation, migration and migration |
| ZEB-AS1 | miR-342-3p [227] | CUL4B | Increase | Promote cell proliferation, migration and invasion through PI3K/AKT/mTOR signaling pathway |
| LINC00665 | miR-1224-5p [228] | SND1 | Increase | Promote cell growth and metastasis |
| SNH3 | miR-577 [229] | SMURF1 | Increase | Promote cell proliferation, migration, EMT and resistant apoptosis |
| FEZF1-AS1 | miR-25-3p [230] | ITGB8 | Increase | Promote cell viability and EMT; Inhibit cell autophagy |
| CRNDE | miR-101 [231] | Rap1A | Increase | Promote cell proliferation, migration and invasion; decrease apoptosis |
| FER1L4 | miR-92a-3p [232] | FBXW7 | Decrease | Inhibit cell proliferation and promote cell apoptosis |
| HOXA11-AS | miR-518b [233] | ACTN4 | Increase | Promote cell proliferation, migration and inhibit apoptosis |
| VPS9D1-AS1 | miR-4739 [234] | MEF2D | Increase | Promote cell proliferation, migration, invasion and inhibit apoptosis |
| HCP5 | miR-4656 [235] | CEMIP | Increase | Promote proliferation, colony formation and inhibit apoptosis |
| LSAMP-AS1 | miR-183-5p [113] | DCN | Decrease | Inhibit cell proliferation migration, invasion and EMT |
| RBMS3-AS3 | miR-4534 [236] | VASH1 | Decrease | Inhibit cell proliferation, migration, invasion and angiogenesis |
| SNHG4 | miR-377 [237] | ZIC5 | Increase | Promote cell growth, migration and invasion |
| SHNG20 | miR-6516 [238] | SCGB2A1 | Increase | Promote cell proliferation, invasion and suppress apoptosis |
| FOXP4-AS1 | miR-3184-5p [239] | FOXP4 | Increase | Promote cell proliferation and decrease cell apoptosis |
| SNHG15 | miR-338-3p [240] | FKBP1A | Increase | Promote cell proliferation, migration, invasion, viability and EMT |
| LEF1-AS1 | miR-330 [241] | LEF1 | Increase | Promote cell proliferation, invasion and migration |
| MEG3 | miR-9-5p [97] | QKI-5 | Decrease | Inhibit proliferation, migration, invasion and induce apoptosis |
| FOXC2-AS1 | miR-1253 [242] | EZH2 | Increase | Promote cell proliferation and tumor growth |
| MYU | miR-184 [243] | Myc | Increase | Promote cell growth and migration |
| PCSEAT | miR-143-3p/24-2-5p [244] | EZH2 | Increase | Promote cell growth and mobility |
| PCAT3/PCAT9 | miR-203 [245] | SNAI2 | Increase | Promote cell proliferation, invasion, migration, angiogenesis and stemness |
| FENDRR | miR-18a-5p [208] | RUNX1 | Decrease | Inhibit cell proliferation, migration, invasion and induce apoptosis |
| CASC2 | miR-183 [114] | Sprouty2 | Decrease | Inhibit cell proliferation and induce apoptosis |
| ANRIL | let-7a [164] | TGF-b1/Smad | Increase | Promote cell proliferation and migration |
| XIST | miR-23a [109] | RKIP | Decrease | Inhibit cell proliferation and tumor metastasis |
| GAS5 | miR-103 [107] | AKT-mTOR | Decrease | Inhibit cell proliferation, invasion and migration |
| OGFRP1 | miR-124-3p [246] | SARM1 | Increase | Promote cell growth and metastasis |
| PROX1-AS1 | miR-647 [247] | Increase | Promote cell proliferation and invasion | |
| ZFAS1 | miR-135-5p [248] | Increase | Promote proliferation, migration, invasion, EMT and inhibit apoptosis | |
| TTN-AS1 | miR-1271 [249] | Increase | Promote cell proliferation and migration | |
| AFAP1-AS1 | miR-512-3p [250] | Increase | Promote cell proliferation, migration and invasion | |
| CASC15 | miR-200a-3p [251] | Increase | Promote cell migration and invasion | |
| HCG11 | miR-543 [252] | PI3K/AKT | Decrease | Inhibit cell proliferation, invasion, migration and induce apoptosis |
| LINC00662 | miR-34a [253] | Increase | Promote cell proliferation, invasion, migration and suppress apoptosis | |
| LncRNA APP | miR-218 [85] | ZEB2/CDH2 | Increase | Promote cell migration and invasion |
| CHRF | miR-10b [254] | cyclinD1/CDK4/6 | Increase | Promote cell proliferation, EMT and repress apoptosis |
| TTTY15 | let-7 [204] | CDK6/FN1 | Increase | Promote cell growth in vivo and in vitro |
| Linc00581 | miR-216b-5p [255] | GATA6 | Increase | Promote cell viability |
| RNCR3 | miR-85-5p [256] | BRD8 ISO2 | Increase | Promote cell proliferation, invasion and colony formation |
| HOTTIP | miR-216a-5p [257] | Increase | Promote cell proliferation, migration and invasion | |
| PCGEM1 | miR-148a [258] | Increase | Inhibit early cell apoptosis | |
| PCAT-1 | miR-145-5p [259] | FSCN1 | Increase | Promote proliferation, migration, invasion and repress apoptosis |
| lncRNA625 | miR-432 [260] | TRIM29/PYGO2 | Decrease | Inhibit cell proliferation and promote cell apoptosis |
| SChLAP1 | miR-198 [53] | MAPK1 signaling | Increase | Promote cell proliferation, invasion and repress apoptosis |
| H19 | miR-657 [261] | TGFB1 | Repress cell migration and cancer metastasis |