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. 2022 Jan 19;11(3):324. doi: 10.3390/cells11030324

Figure 1.

Figure 1

Food intake response in fasting animals after LEAP-2 administration. (A) Dose-response and time-response to ICV LEAP-2 administration (0.45 nmol/mice or 1.5 nmol/mice) on food intake (g) in mice. ** p < 0.01 between control and LEAP-2 (1.5 nmol/mice) and # p < 0.05, ## p < 0.01 between control and LEAP-2 (2 μg/mice). (B) Circulating levels of LEAP-2 in mice in fed or under overnight fasting. (C) Food intake after LEAP-2 (1.5 nmol/mice) administration in mice fasting overnight (left panel) and Glucose levels before and after 2 h of LEAP-2 administration (right panel). n = 6. (D) Circulating levels of LEAP-2 in ob/ob mice and control. (E) Food intake after LEAP-2 administration in ob/ob mice (left panel) and Glucose levels before and after 2 h of LEAP-2 administration (right panel). n = 6. (F) Circulating levels of LEAP-2 in obese mice induced by diet (HFD) and control (G) Food intake after LEAP-2 administration in HFD mice fasting overnight (left panel) and Glucose levels before and after 2 h of LEAP-2 administration (right panel). n = 8. (H) Circulating levels of LEAP-2 in rats in fed or under overnight fasting. (I) Food intake after LEAP-2 administration in rats (8 nmol/mice) fasting overnight. n = 7. Data is expressed as mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001 between vehicle and LEAP-2.