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. 2022 Jan 22;11(3):371. doi: 10.3390/cells11030371

Figure 2.

Figure 2

Overview on Orai1 N-terminal or loop2 regions involved in interactions with internal proteins, gating, the regulation by lipids or intracellular pH and, among others, CRAC channel inactivation. AC8: adenylyl cyclase 8, AKAP: A-kinase anchoring protein, Cav: Caveolin, CaM: Calmodulin, CCT: chaperonin-containing T-complex protein 1, CRACR2A: CRAC regulator 2A, ETON: extended transmembrane Orai1 N-terminal region, FCDI: fast Ca2+ dependent inactivation, SOGI: STIM1-Orai1 gating interface, TM: transmembrane.