Effect of Le. mesenteroides, Ll. curvatus, or Lp. plantarum-derived ECVs (LmV, LcV, or LpV) on LPS-induced phosphorylation of Erk and p38 in microglia (A–C). The cells were pretreated with the LmV, LcV, or LpV (2.5 and 5.0 μg/mL) for 2 h, followed by treatment with the LPS (0.5 μg/mL) for 30 min. The Erk, p-Erk, p38, and p-p38 levels in each sample were normalized to the β-actin levels. Control and LPS were control cells (LPS and sample-untreated cells) and LPS group cells (cell treated with the LPS only), respectively. The phosphorylation of Erk and p38 was abbreviated by p-Erk and p-p38. Values are expressed as the mean ± SD (n = 4) and those followed by different letters (a–f) within a property are significantly different (p < 0.05) according to Duncan’s multiple range test.