Figure 1.

Flowchart visualizing study design and aims. (A) Data from SF3B1^mut UM from 11 cohorts were collected and described with stratification criteria. (B) Differential gene expression analysis (DGE) was performed and the ROMS, and TCGA-UVM data were intersected to investigate SF3B1^mut specific transcripts. (C) DGE was performed on SF3B1^mut-only samples using the PFS stratification criteria to investigate transcript expression characteristic for early onset (PFS < 60) and late onset (PFS ≥ 60 months). Finally, in silico results were validated in vitro.