Figure 6.

SF3B1^mut UM is characterized by aberrant splicing events. Unsupervised clustering (Euclidean distances and Ward.D2 method) on the differential exon usages between SF3B1^mut samples in the ROMS cohort with PFS < 60 months and PFS ≥ 60 months. Values are mean-centered read counts represented with a z score of differentially expressed splicing events in genes (blue, low expression; red, high expression). Top bars represent PFS-status (yellow; PFS < 60 months and purple; PFS ≥ 60 months). Asterisk (*) indicates novel splicing aberrations that are either donors or acceptors.