Figure 2.

Transformed cells have larger nucleoli and increased ribosome production. The nucleolus increases in size and density to accommodate the need for ribosome production. In transformed cells frequently due to hyperactivation of MYC, nucleoli are larger in size and darker in color, indicating higher activity, which results in an increase in ribosome number. Containing a larger number of ribosomes amplifies mRNA translation and ultimately leads to an increase in cell growth. Figure created with Biorender.com (accessed on 5 January 2022).