Table 1.
Comparison of tumor engraftment and tumor growth rate according to the development of patient-derived xenograft models.
| Successful Engraftment | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Diagnosis | Case | Successful Engraftment | Failed Engraftment | Successful Engraftment Rate (%) | p Value a | Duration b (Month) | p Value c | Tumor Growth Rate b | p Value d |
| Ovarian cancer, n | <0.0001 | 0.0021 | |||||||
| P1 | 130 | 61 | 69 | 46.92 | 6.70 ± 3.95 | 319.3 ± 319.7 | reference | ||
| P2 | 61 | 55 | 6 | 90.16 | 4.93 ± 3.55 | 575.1 ± 613.3 | 0.0145 | ||
| P3 | 55 | 52 | 3 | 94.55 | 4.09 ± 2.85 | 527.5 ± 457.9 | 0.0168 | ||
| Cervical and Vaginal cancer, n | 0.0004 | 0.0007 | |||||||
| P1 | 45 | 29 | 16 | 64.44 | 5.42 ± 2.74 | 606.7 ± 527.0 | reference | ||
| P2 | 29 | 26 | 3 | 89.66 | 3.19 ± 1.57 | 558.7 ± 594.6 | 0.7828 | ||
| P3 | 26 | 26 | 0 | 100 | 3.10 ± 1.61 | 525.2 ± 394.5 | 0.5891 | ||
| Uterine cancer, n | 0.014 | 0.08 | |||||||
| P1 | 32 | 18 | 14 | 56.25 | 6.04 ± 4.13 | 427.3 ± 507.2 | reference | ||
| P2 | 18 | 17 | 1 | 94.44 | 4.11 ± 3.15 | 449.8 ± 339.0 | 0.8992 | ||
| P3 | 17 | 13 | 4 | 76.47 | 2.80 ± 1.48 | 1208 ± 1204 | 0.0341 | ||
a Chi-square test values for success and failure. b Values are mean ± standard derivation. c One-way ANOVA test among P1, P2, and P3. d Unpaired t-test values for growth rate of P2 or P3 compared to P1.