Figure 1.

Current zebrafish models for Dravet Syndrome. SCN1A haploinsufficiency in DS patients is modeled by homozygous disruption of one of the two zebrafish paralogs. Disruption is achieved via gene knockdown, missense mutations, or gene knockout introduced by different technologies. References for each model from top to bottom; scn1laa^−/− [This publication], scn1laa^sa1674 [8], scn1lab MO [3], scn1lab^s552 [4], scn1lab^sa16474 [9], scn1lab^−/− [5], scn1lab^∆44 [10], scn1lab^mut/mut [1]. Figure made with Biorender.