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. 2022 Jan 27;11(3):444. doi: 10.3390/cells11030444

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Histology and immunohistochemistry of a brain vessel with fibrin, PMNs, inflammatory T lymphocytes, and reactive astrocytes in the brain of a COVID-19 patient. Photo (A) shows a blood vessel in the brain filled with neutrophils (red arrows) and fibrin (blue arrows), (HE, 400×). Photo (B) shows a perivascular infiltrate of immunohistochemically CD3-positive T lymphocytes (arrow) in the cerebral vein (DAB, 200×). Photo (C) shows immunohistochemically MPO-positive PMNs in a cerebral blood vessel (arrow), (DAB, 100×), while Photo (D) shows immunohistochemically SOD2-positive diffuse reactive astrocytes in white matter of the brain (dark brown shows DAB staining; some are indicated by blue arrows) and inflammatory cells in a blood vessel (red arrow) (DAB, 100×).