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. 2022 Jan 27;11(3):444. doi: 10.3390/cells11030444

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Histology and immunohistochemistry of the heart tissue of a COVID-19 patient with myocarditis. Photo (A) shows inflammatory cells (blue arrow) in edematous myocardial endomysium and the foci of myophagocytosis (red arrow) (HE, 200×). In Photo (B), immunohistochemically CD68-positive macrophages are present in the myocardium, being active in myophagocytosis (arrow), (DAB, 200×). Photo (C) shows immunohistochemically brown-stained CD3-positive T lymphocytes in the endomysium (DAB, 100×). Photo (D) shows an immunohistochemically positive reaction for MPO of PMNs in myocardial blood vessels and their spread in perivascular space (arrows), (DAB, 400×).