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. 2022 Jan 27;11(3):444. doi: 10.3390/cells11030444

Table 1.

Major clinical and autopsy findings of patients deceased after lethal COVID-19.

Age Sex Comorbidity Diagnoses Organ Tissue Findings Inflammatory Cells * Bleeding Thrombosis Edema
58 M DM2 1 ARDS 2 lungs DAD 3, interstitial pneumonia Ly, Pl, Ma, PMN 4 no yes yes
Hypertension pulmonary emboly
pneumonia interstitialis
heart myocardial fibrosis atherosclerosis PMN no no yes
Steatosis hepatis atherosclerosis
dilatatio cordis brain brain edema PMN, Mo yes no yes
54 M Obesity
Hypertension
ARDS (DAD) lungs DAD, inerstitial pneumonia, DIC Mo, PMN yes no yes
pneumonia
DIC 5 brain edema, DIC PMN, Mo yes yes yes
myocardial fibrosis
hypertrophia and dilatatio cordis
heart myocardial fibrosis Mo no no no
steatosis hepatis
renal ATN 7
liver steatosis hepatis Mo no no no
55 M Hypertension (sepsis staphylococcica)
ARDS (DAD)
lungs DAD, pneumonia abscedens PMN no no yes
pneumonia abscedens brain brain edema Ly. PMN, Mo no no yes
steatosis hepatis liver steatosis hepatis Ly, PMN no no no
atherosclerosis
heart dilatation
heart myocardial fibrosis PMN no no no
57 6 M (sepsis A. baumanii), ARDS (DAD) lungs pneumonia chronica and suppurativa, DAD Ma, Mo, Ly, Pl, PMN yes yes yes
pneumonia kidney renal ATN PMN no no no
renal ATN heart myocardial fibrosis and lipomatosis Ly no no no
myocardial fibrosis liver centrilobular cyanosis Ly no no no
brain brain edema Ly, Mo no no no
65 M DM2 bilateral pneumonia heart myocardial fibrosis Ly, Mo, PMN no no no
Hypertension
Hyperlipidemia
pulmonary microthrombosis lungs lung fibrosis, Chronic DAD, acute hemorrhage Ma, PMN yes yes yes
Atherosclerosis atherosclerosis kidney renal ATN PMN no no no
IBD 8 heart hypertrophia liver steatosis hepatis Ly, PMN no no no
myocardial fibrosis heart myocardial fibrosis PMN no no no
brain brain edema Ly no no no
11 M MIS 9, ARDS (DAD) lungs ARDS (DAD) Mo, Ly yes no yes
myocarditis encephalitis heart myocarditis
edema cerebri brain encephalitis, edema PMN, Ly, Ma no no no
MOF 10, renal ATN kidney renal ATN PMN no no no
centrilobular liver necrosis liver autolysis PMN, Mo no no yes
74 F DM2 ARDS
Hypertension steatosis hepatis
myocardial fibrosis
liver hepatic centrilobular necrosis Ly no no no
heart dilatation
pneumonia lungs DAD, interstitial pneumonia PMN, Ma yes no yes
renal ATN kidney renal ATN PMN yes no yes
myocardial fibrosis heart myocarditis PMN, Ly no no no
65 6 M Atherosclerosis
ARDS (DAD)
pneumonia
lungs DAD, pneumonia suppurativa, no yes yes
Hypertension
hematoma intracerebrale brain acute bleeding and brain edema PMN, Ly yes no yes
Obesity hematocephalus
myocardial fibrosis heart myocardial fibrosis PMN no no no
75 M Atherosclerosis ARDS (DAD)
interstitial pneumonia lungs pneumonia, DAD PMN, Mo, Ly no no yes
myocardial fibrosis, heart dilatation and hypertrophy heart myocardial fibrosis PMN, Ly no no no
renal ATN kidney renal ATN PMN no no no

1 diabetes mellitus type 2; 2 acute respiratory distress syndrome; 3 diffuse alveolar damage; 4 lymphocytes (Ly), plasma cells (Pl), macrophages (Ma), polymorphonuclear leukocytes (PMN), monocytes (Mo); 5 disseminated intravascular coagulation; 6 patient was supported by extracorporeal membrane oxygenation (ECMO); 7 acute tubular necrosis; 8 inflammatory bowel disease; 9 multisystem inflammatory syndrome; 10 multiple organ failure; * inflammatory cells that were the most pronounced.