Table 1.
Most relevant pathways altered in 1-day-old DJ-1β mutants compared to control flies.
| Pathway | Number of Differential Metabolites/Totals | Raw p-Value | p-Value FDR Corrected | Impact |
|---|---|---|---|---|
| beta-Alanine metabolism | 2/14 | 4.21 × 10−15 | 1.43 × 10−13 | 0.28 |
| Histidine metabolism | 2/9 | 7.51 × 10−13 | 8.51 × 10−12 | 0.40 |
| Alanine, aspartate and glutamate metabolism | 6/23 | 2.20 × 10−12 | 1.87 × 10−11 | 0.19 |
| Glyoxylate and dicarboxylate metabolism | 6/24 | 4.07 × 10−10 | 1.54 × 10−19 | 0.17 |
| Phenylalanine, tyrosine and tryptophan biosynthesis | 1/4 | 1.61 × 10−9 | 4.98 × 10−9 | 0.50 |
| Phenylalanine metabolism | 1/7 | 1.61 × 10−9 | 4.98 × 10−9 | 0.38 |
| Glutathione metabolism | 1/26 | 3.84 × 10−9 | 9.33 × 10−9 | 0.09 |
| Glycine, serine and threonine metabolism | 3/30 | 1.35 × 10−8 | 2.90 × 10−8 | 0.33 |
| Pyruvate metabolism | 4/22 | 1.36 × 10−8 | 2.90 × 10−8 | 0.28 |
| Glycerophospholipid metabolism | 2/32 | 1.73 × 10−8 | 3.36 × 10−8 | 0.11 |
| Citrate cycle (TCA cycle) | 5/20 | 9.,20 × 10−7 | 1.56 × 10−6 | 0.24 |
| Glycolysis/Gluconeogenesis | 4/26 | 3.25 × 10−5 | 4.81 × 10−5 | 0.13 |
| Arginine biosynthesis | 3/12 | 7.25 × 10−5 | 1.03 × 10−4 | 0.40 |
| Cysteine and methionine metabolism | 2/32 | 2.29 × 10−4 | 3.11 × 10−4 | 0.14 |
| Taurine and hypotaurine metabolism | 1/7 | 4.72 × 10−3 | 5.48 × 10−3 | 0.20 |
| Arginine and proline metabolism | 2/31 | 4.84 × 10−3 | 5.48 × 10−3 | 0.17 |
This table presents the most significant pathways (p-value FDR corrected < 0.05) with a considerable impact power, which were altered in 1-day-old DJ-1β mutant compared to control flies. In particular, the number of differential metabolites/total indicates matched the number of metabolites in the total number of compounds in the pathway; raw p-value is the original p-value calculated from the enrichment analysis; p-value FDR corrected is the p-value adjusted using False Discovery Rate; the impact is the pathway impact value calculated from pathway topology analysis.