Table 3.
Most relevant pathways altered in 15-day-old compared to 1-day-old DJ-1β mutants.
| Pathway | Number of Differential Metabolites/Totals | Raw p-Value | p-Value FDR Corrected | Impact |
|---|---|---|---|---|
| Glycerophospholipid metabolism | 2/32 | 1.85 × 10−5 | 6.29 × 10−4 | 0.11 |
| Alanine, aspartate and glutamate | 6/23 | 1.98 × 10−4 | 3.36 × 10−3 | 0.19 |
| Citrate cycle (TCA cycle) | 5/20 | 4.54 × 10−3 | 2.57 × 10−2 | 0.24 |
| Phenylalanine, tyrosine and tryptophan biosynthesis | 1/4 | 7.60 × 10−3 | 2.87 × 10−2 | 0.50 |
| Phenylalanine metabolism | 1/7 | 7.60 × 10−3 | 2.87 × 10−2 | 0.38 |
This table presents the most significant pathways (p-value FDR corrected < 0.05) with a considerable impact power, which were altered between 1-day-old and 15-day-old DJ-1β mutant flies. In particular, the number of differential metabolites/total indicates matched number of metabolites in the total number of compounds in the pathway; raw p-value is the original p-value calculated from the enrichment analysis; p-value FDR corrected is the p-value adjusted using False Discovery Rate; the impact is the pathway impact value calculated from pathway topology analysis.