TABLE 3.

Summary of the differentially expressed metabolites between PHx and PHx+ AR113 groups.

m/z	Ion mode	Metabolites	VIP	P-value	FC
132.10171	Pos	L-Isoleucine	3.38	0.0014	0.75
130.08765	Neg	L-Leucine	2.28	0.0083	0.70
552.27106	Neg	Vignatic acid A	3.58	0.0000	3.18
355.06781	Pos	6-[5-(2-carboxyeth-1-en-1-yl)-2,3-dihydroxyphenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid	3.87	0.0000	1.79
403.23215	Pos	5S-HETE di-endoperoxide	2.28	0.0000	21.29
186.11375	Neg	7-oxo-8-amino-nonanoic acid	2.85	0.0003	3.31
129.05583	Neg	Mevalonic acid	1.87	0.0035	0.56
506.32298	Neg	PC(17:1(10Z)/0:0)	1.33	0.0280	0.89
904.58372	Pos	PC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:4(7Z,10Z,13Z,16Z))	3.28	0.0004	1.99
904.5835	Pos	PC(22:4(7Z,10Z,13Z,16Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	1.83	0.0000	1.94
478.29196	Pos	LysoPE(18:2(9Z,12Z)/0:0)	2.93	0.0433	0.67
500.277	Neg	LysoPE(20:4(5Z,8Z,11Z,14Z)/0:0)	3.30	0.0276	0.69
438.29619	Pos	PE(P-16:0/0:0)	2.83	0.0200	0.51
500.27645	Neg	LysoPE(0:0/20:4(5Z,8Z,11Z,14Z))	1.48	0.0211	0.71
763.53652	Pos	1-(6-[3]-ladderane-hexanoyl)-2-(8-[3]-ladderane-octanyl)-sn-glycerophosphoethanolamine	1.20	0.0096	1.47
885.54815	Neg	PI(20:4(5Z,8Z,11Z,14Z)/18:0)	7.30	0.0163	1.63
909.54695	Neg	PI(20:3(5Z,8Z,11Z)/20:3(8Z,11Z,14Z))	1.29	0.0389	1.46
504.27176	Neg	1-Oleoylglycerophosphoserine	4.20	0.0000	2.42
506.28682	Neg	1-(2-methoxy-6Z-heptadecenyl)-sn-glycero-3-phosphoserine	3.08	0.0000	2.73
401.07701	Neg	4-Phosphopantothenoylcysteine	2.24	0.0463	1.39
380.25588	Neg	Sphinganine 1-phosphate	2.53	0.0277	0.55
466.33424	Pos	1alpha,25-dihydroxy-24a-homo-22-thiavitamin D3/1alpha,25-dihydroxy-24a-homo-22-thiacholecalciferol	2.23	0.0200	0.61
480.30672	Pos	PE(18:1(9Z)/0:0)	3.11	0.0143	0.61
72.080461	Pos	Pyrrolidine	2.24	0.0008	0.59
86.096214	Pos	Piperidine	3.04	0.0006	0.74
201.03839	Neg	Chrycorin	3.05	0.0007	1.42

Pos, positive ion mode; Neg, negative ion mode.